The Marlton Hotel was built in 1900 and known for much of its life as The Marlton House. Through its history, Marlton House was home to artists, actors and other creative people in need of an affordable place to stay. The long list of infamous and soon-to-be-famous guests who once took up residency at Marlton House includes Jack Kerouac, who wrote The Subterraneans and Tristessa while living at the hotel, and Neil and Carolyn Cassady. Valerie Solanas was staying in The Marlton when she shot Andy Warhol. Lenny Bruce, Julie Andrews, and Mickey Rourke all stayed at the hotel over the years as well.

In 2012, the landmarked building was lovingly restored by Sean MacPherson.